<p>Novel <em>N</em>-(Substituted) Thioacetamide Quinazolinone Benzenesulfonamides as Antimicrobial Agents</p>
نویسندگان
چکیده
منابع مشابه
4-amino-substituted benzenesulfonamides as inhibitors of human carbonic anhydrases.
A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay and isothermal titration calorimetry. The results showed that 4-substituted diazobenzenesulfonamides were more potent CA binders than N-aryl-β-al...
متن کاملSynthesis and Antimicrobial Study of Pyrimidinone Substituted 4(3H)-Quinazolinone Derivatives
Heterocyclic scaffold has been under discovery due to their considerable therapeutic and medicinal importance. One of such heterocycles 2-pyrimidinone, while not naturally occurring, are receiving increased attention because of their wide-ranging biological activity like, an efficient inhibitor of DNA synthesis in E. coli, inhibitors of the enzyme cytidinedeaminase, and as metaphase inhibitors....
متن کاملSynthesis of Rhodanine Substituted 4(3H)-Quinazolinone Derivatives and their Antimicrobial Evaluation
Heterocyclic scaffold including nitrogen, sulfur and oxygen has been under exploration due to their significant therapeutic and medicinal properties. Among these types of molecules, 4thiazolidinones have displayed various important biological activities. Especially rhodanine (2-thioxothiazolidine-4-ones) derivatives represent privileged scaffolds in drug discovery, due to the presence of >N–C–S...
متن کاملSynthesis and Anti-Denaturation Activity of Some Substituted Quinazolinone Analogs
In recent years there is a tremendous increase of inflammatory cases, leading to the design and development of newer anti-inflammatory agents. The reaction of 2-substituted phenyl-3-chloroacetamido quinazolin-4(3H)-ones with various 5-phenyl-1,3,4-oxadiazole-2-thiol and 5-(pyridine-4-yl)-1,3,4-oxadiazole-2thiol gave N-(4-Oxo-2-substituted phenylquinazolin-3(4H)-yl)-2-[(5-aryl-1,3,4-oxadiazol-2-...
متن کاملUses of 2-Ethoxy-4(3H) quinazolinone in Synthesis of Quinazoline and Quinazolinone Derivatives of Antimicrobial Activity: The Solvent Effect
2- Ethoxy-4(3H) quinazolinone 1 was synthesized and allowed to react with various halides, namely: alkyl, benzyl, allyl, acyl, haloacetyl, crotonyl, benzoyl, 2-furoyl and 1-naphthalenesulphonyl halides affording quinazoline and quinazolinone derivatives. The reactions of compound 1 with phosphorus oxychloride, phosphorus pentasulfide, ethyl chloroformate, ethyl chloroacetate, ?-bromoglucose tet...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2020
ISSN: 1178-2013
DOI: 10.2147/ijn.s241433